

Players have the ability to shot dodge, during which the player dives in any direction with a slow-motion effect. The special cars include "Conquistador", Orange Dirtbike, Purple and Flame Pickup, Tow Truck, DEA, and Military SUVs. The game features cheap and special cars.

While outside the missions the player can explore the open world of the game, but some regions will be available only during certain missions. Throughout the game, players can run and dive and have the ability to use weapons including shotguns, rifles, handguns, and rocket launchers. The game parodies Robert Rodriguez's Mexico Trilogy. The most playable character in the game is Ramiro, while Tommy and Ernesto can be played only in the two beginning missions. Players assume control of Ramiro, Tommy, and Ernesto. Total Overdose is a third-person shooter open-world action/adventure game.
